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Neoplasm, Hamartoma, Teratoma, Hyperplasia

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All of those conditions are types of different cell growth disturbances. In this article, I'll only try to mention the main tricky differences between them.

Neoplasm

  • local growth, but may spread (direct invasion, or metastasis)
  • of a monoclonal origin
  • may or may not resemble the tissue of origin
  • its growth is uncoordinated & uncontrolled even if the cause or the original tissue growth stops
  • subtypes: Benign, Malignant, Locally malignant

Hamartoma

  • resembles Neoplasm (grossly & microscopically)
  • local coordinated growth
  • controlled i.e. stops its growth if the cause or the original tissue growth stops
  • e.g. hemangioma, lymphangioma

Teratoma

  • non-local/foreign — arises from other tissues
  • is actually a neoplasm
  • common targets: ovaries – testis

Hyperplasia

  • is of a polyclonal origin
  • not as risky as neoplasm
  • occurs due to physiological factors (female breast at puberty) or pathological factors (hormonal hypersensitivity)


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